Whey protein concentrates-polysaccharides based microcapsules for controlled release of folic acid | |
| Author | Nongnard Jaroensri |
| Call Number | AIT Thesis no.FB-10-14 |
| Subject(s) | Folic acid Controlled release technology Whey products Polysaccharides Microencapsulation |
| Note | A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in F ood Engineer ing and Bioprocess Technology, School of Environment, Resources and Development |
| Publisher | Asian Institute of Technology |
| Series Statement | Thesis ; no. no.FB-10-14 |
| Abstract | Microcapsules for controlled release of folic acid were produced using whey protein concentrate (WPC) - polysaccharides (Ps) as the wall materials. WPC and three different polysaccharides namely sodium alginate (A), xanthan gum (X) and exopolysaccharide from Cordyceps dipterigera BCC2073 (EPS2073 ) were used. Before encapsulation by emulsification/ internal gelation techniques, the ratio of WPC - Ps and other variables such as emulsifier concentrations, Ps solution: soybean oil ratio and concentration of Ps solution were optimized for effective produ ction of the microcapsules. The pH a nd WPC: Ps ratio had an effect on the WPC - Ps complexation. Decrease in aqueous volume fraction and increase in concentration of polysaccharide solution cause increase in water - in - oil emulsion stability. The three microca psule types, A - WPC, X - WPC and EPS2073 - WPC microcapsules were characterized for their shape, color, encapsulation efficiency (EE) and loading efficiency (LE). Moreover the microcapsules were studied their capsule size and folic acid release in simulate d gas tric fluid (SGF pH 1.2), acetate buffer (pH 4.5) and stimulate d intestinal fluid (SIF pH 6.8). The A - WPC microcapsules provide the highest EE and LE followed by X - WPC and EPS 2073 - WPC microcapsules, respectively. All of microcapsules had a spherical shape w ith less than 20 μm in size. All of the microcapsules had swollen in such media . The A - WPC microcapsules wa s the most effective microcapsules which can resist in gastric and acetate buffer pH 4.5 with very low releasing (<20% of folic acid encapsulated) th roughout incubation period. While, X - WPC microcapsules give the moderately release and EPS2073 - WPC microcapsules give the highest release up to 80% in medium pH 1.2. |
| Year | 2010 |
| Corresponding Series Added Entry | Asian Institute of Technology. Thesis ; no. no.FB-10-14 |
| Type | Thesis |
| School | School of Environment, Resources, and Development (SERD) |
| Department | Department of Food, Agriculture and Natural Resources (Former title: Department of Food Agriculture, and BioResources (DFAB)) |
| Academic Program/FoS | Food Engineering and Bioprocess Technology (FB) |
| Chairperson(s) | Anil Kumar Anal; |
| Examination Committee(s) | Athapol Noomhorm;Sudip Kumar Rakshit; |
| Scholarship Donor(s) | Wai Prathumpai; |
| Degree | Thesis (M. Sc.) - Asian Institute of Technology, 2010 |