Development of PLA based scaffold structure using SVM technique | |
| Author | Irwansyah |
| Call Number | AIT Thesis no.ISE-08-23 |
| Subject(s) | Rapid prototyping Tissue engineering |
| Note | A thesis submitted in partial fulfillment of the re quirements for the degree of Master of Engineering in Design & Manufacturing Engineering, School of Engineering and Technology |
| Publisher | Asian Institute of Technology |
| Series Statement | Thesis ; no. ISE-08-23 |
| Abstract | The emerging discipline of tissue engineering offers realistic alternative to replace failing organs and aging cells with healthy cells and neo tissues grown. The process generally consists of the isolation of cells from a patient and growth on three-dimensional templates or scaffolds. In order to build tissue engineering scaffold, selective vacuum manufacturing (SVM) technique as one of rapid prototyping technique has been developed. Therefore, the feasibility of SVM technique to fabricate scaffold has been explored. In addition, the characteristics of scaffold including porosity, particle size, interconnectivity and mechanical properties have been also investigated. Consequently, researches have been addressed in two phases. In the first phase, an alpha prototype of SVM machine has been developed. The Polylactic acid (PLA) has been selected as scaffold material. In the second phase, process parameters of SVM technique have been identified. The scaffolds have been fabricated in three patterns (solid cylinder, zigzag and 0°/90°). By controlling process parameters of SVM technique, the scaffold with 0°/90° pattern has presented high porosity, short toolpath, maintained geometry shape and appropriate mechanical properties. As a result, it can be concluded that SVM technique is feasible employed to fabricate tissue engineering scaffold. |
| Year | 2008 |
| Corresponding Series Added Entry | Asian Institute of Technology. Thesis ; no. ISE-08-23 |
| Type | Thesis |
| School | School of Engineering and Technology (SET) |
| Department | Department of Industrial Systems Engineering (DISE) |
| Academic Program/FoS | Industrial Systems Engineering (ISE) |
| Chairperson(s) | Pisut Koomsap |
| Examination Committee(s) | Manukid Parnichkun;Trung Luong Huynh |
| Scholarship Donor(s) | Syiah Kuala University;Government of Nanggro Aceh Darussalam Indonesia |
| Degree | Thesis (M.Eng.) - Asian Institute of Technology, 2008 |