Investigation of applying electrospinning in fused deposition modelling for scaffold fabrication | |
| Author | Kampanat Auyson |
| Call Number | AIT Thesis no.ISE-12-09 |
| Subject(s) | Electrospinning Scaffolding |
| Note | A thesis submitted in partial fulfillment of the requirements for the degree of Master of Engineering in Industrial and Manufacturing Engineering, School of Engineering and Technology |
| Publisher | Asian Institute of Technology |
| Series Statement | Thesis ; no. ISE-12-09 |
| Abstract | Rapid prototyping (RP) has been applied in tissue engineering for creating a scaffold with controllable architecture that is difficult to achieve with conventional scaffold fabrication techniques. However, the diameter of filament produced with RP techniques may be limited to micro level. Nano filament, on the other hand, can be easily achieved but with uncontrollable architecture by electrospinning, another scaffold fabrication process. The integration of RP and electrospinning has been foreseen to allow nano scaffold to be created with controllable architecture, and this research has been conducted to investigate the possibility of this integration. Fused deposition modeling (FDM) has been a selected RP technique as its process is closest to electrospinning. Series of experiments have been conducted to solve a jet discontinuity, to solve bending instability and to fabricate layers of scaffolds according to identified process conditions. From the experimental results, it was found that voltage is a significant factor for creating a continuous jet, and bending instability can be avoid by having a standoff distance (SOD) within the distance before the jet starts bending. Polycaprolactone (PCL) dissolved dimethylformamide (DMF) has been used as scaffold material in this study. The smallest diameter obtained was 19 μm on average that could be obtained by applying the voltage of 3.2 kV to a solution of 10 wt% of PCL in DMF. The needle tip was set 5 mm above a collector that travelled at the speed of 40 mm/s. Scaffold were fabricated and tested for their mechanical property. The ultimate tensile strength, Young modulus and maximum strains were reported 0.55 MPa, 2.05 MPa and 35 % on average, respectively. |
| Year | 2012 |
| Corresponding Series Added Entry | Asian Institute of Technology. Thesis ; no. ISE-12-09 |
| Type | Thesis |
| School | School of Engineering and Technology (SET) |
| Department | Department of Industrial Systems Engineering (DISE) |
| Academic Program/FoS | Industrial Systems Engineering (ISE) |
| Chairperson(s) | Pisut Koomsap;Pitt Supaphol; |
| Examination Committee(s) | Voratas Kachitvichyanukul;Huynh Trung Luong; |
| Scholarship Donor(s) | Royal Thai Government Fellowship; |
| Degree | Thesis (M.Eng.) - Asian Institute of Technology, 2012 |