Design and simulation of sinusoidal microchannel for cell separation system using inertial focusing technique | |
| Author | Ishaque, Muhammad |
| Call Number | AIT Thesis no.ISE-12-10 |
| Subject(s) | Cell separation--Technique Microfluidic devices Microelectromechanical systems |
| Note | A thesis submitted in partial fulfillment of the requirements for the degree of Master of Engineering in Industrial and Manufacturing Engineering, School of Engineering and Technology |
| Publisher | Asian Institute of Technology |
| Series Statement | Thesis ; no. ISE-12-10 |
| Abstract | In this thesis we report on an uncomplicated inertial microfluidic device that attains uninterrupted particle focusing employing the theory of Dean-joined inertial immigra- tion in sinusoidal microchannel. The balance of inertial forces as well as the Dean rotating forces compels the particle to take up a place in the middle of the channels due to sinusoidal geometry. The location at which particles equilibrate was reliant on the relation of the inertial lift to Dean Drag forces. By means of this conception, we exhibit, for the foremost time, a descending curve sinusoidal channel for size- reliant fo- cusing of particles crosswise the micro conduit cross-section. With a properly planned geometry the particle torrents could be accumulated in the middle of the channel. To express this theory, a sinusoidal having different radius of curvatures was utilized to continuously and simultaneously focus 5 μm particle in the middle of the channel. The device demonstrates a successful focusing of the desired particles. The results were in full agreement with theoretical analysis. The straightforward planar construction as well as elevated throughput presented by this passive microfluidic device makes it gorgeous for LOC devices in environmental and biomedical applications. |
| Year | 2012 |
| Corresponding Series Added Entry | Asian Institute of Technology. Thesis ; no. ISE-12-10 |
| Type | Thesis |
| School | School of Engineering and Technology (SET) |
| Department | Department of Industrial Systems Engineering (DISE) |
| Academic Program/FoS | Industrial Systems Engineering (ISE) |
| Chairperson(s) | Afzulpurkar, Nitin V. |
| Examination Committee(s) | Bohez, Erik L.J.;Ampon Poyai;Ashraf, Muhammad Waseem |
| Scholarship Donor(s) | Balochistan University of Engineering and Technology, Paksitan;Asian Institute of Technology Fellowship |
| Degree | Thesis (M. Eng.) - Asian Institute of Technology, 2012 |