Design and simulation of ascending and descending curvilinear micro channels for cancer cell separation from the blood | |
| Author | Wewala, W. A. H. S. S. |
| Call Number | AIT Thesis no.ISE-12-16 |
| Subject(s) | Cell separation--Technique Microfluidics |
| Note | A thesis submitted in partial fulfillment of the requirements for the degree of Master of Engineering in Industrial and Manufacturing Engineering, School of Engineering and Technology |
| Publisher | Asian Institute of Technology |
| Series Statement | Thesis ; no. ISE-12-16 |
| Abstract | Major problems of cancer cell separation are very difficult to separate and identify cells in initial stage due to few amount of cells are presence in the blood. Based on World Health Organization (WHO) statistics, it is clear that thousands of people dying yearly, due to varies types of cancer. Thus it is very important to identify cancer cell in initial stage. This thesis will be very useful for doctors as well as patient, who are suffering with cancer for proper treatment. This works presents the performance and new structure of an Ascending and Descending curvilinear (A and DC) micro-channels for cancer cell separation from the blood. The separation system is designed and simulated to separate cancer cell by using inertia focusing cell separation technique. CFD design and simulation of Ascending and Descending curvilinear (A and DC) micro channel for cell separation using inertia focusing technique is studied. The A and DC micro channels are designed based on theoretical calculation and CFD ACE+ simulation. First step of design is A and DC channel created using CFD- GEOM module, meshed and applied boundary conditions. Final step is simulation using CFD ACE + solver and view the results in CFD ACE +VIEW module. "Graphs are presented that depict the separating efficiency, purity and output to input ratio at different Reynolds numbers and different outlets‖. The simulation results indicate that descending curvilinear micro channel is good agreement for cancer cell separation with 100% separation efficiency and 100% purity than descending curvilinear micro channel. |
| Keyword | Microfluidics; Simulation; MEMS; Microchannel; CFD; cancer cell; Ascending; Descending |
| Year | 2012 |
| Corresponding Series Added Entry | Asian Institute of Technology. Thesis ; no. ISE-12-16 |
| Type | Thesis |
| School | School of Engineering and Technology (SET) |
| Department | Department of Industrial Systems Engineering (DISE) |
| Academic Program/FoS | Industrial Systems Engineering (ISE) |
| Chairperson(s) | Afzulpurkar, Nitin V. |
| Examination Committee(s) | Mongkol Ekpanyapong;Amporn Poyai |
| Scholarship Donor(s) | Technical Education Development Project (TEDP) Sri Lanka;Asian Institute of Technology Fellowship |
| Degree | Thesis (M. Eng.) - Asian Institute of Technology, 2012 |