Design, simulation and fabrication of serpentine microchannel with split flow based on hydrodynamics for continuous cell sorting system | |
| Author | George, Elizabeth |
| Call Number | AIT Thesis no.ISE-12-58 |
| Subject(s) | Microfluidics Microfluidic devices |
| Note | A thesis submitted in partial fulfillment of the requirements for the D egree of Master of Engineering in Mechatronics, School of Engineering and Technology |
| Publisher | Asian Institute of Technology |
| Series Statement | Thesis ; no. ISE-12-58 |
| Abstract | NOTE 520 Microfluidic devices are an integral part of the medical technology. There are both active and passive microfluidic device. In this thesis a passive mechanism for a lab - on - chip devi ce to continuously sort the microparticle is designed and developed. This mechanism is realized by designing a microchannel taking into conside ration only the i ntrinsic properties of the microparticle. The parameters that control the efficiency of the microchannel is the particle size, speed of sample flow, length and shape of the microchannel. The passive device mechanism is based on the princip le of hydrodynamic focusing and hydrophoretic filtration. The device is designed, simulated and analysed in a ESI CFD ACE+ which is a multiphysics software. The device can work only for particles of the range 1 μ m to 10 μ m and is made capable of separa ting three particles of different sizes falling within the prescribed range. Simulations are carried out at different fluid and particles densities and the results are tabulated. The simulated design is also fabricated and basic testing is done. |
| Year | 2012 |
| Corresponding Series Added Entry | Asian Institute of Technology. Thesis ; no. ISE-12-58 |
| Type | Thesis |
| School | School of Engineering and Technology (SET) |
| Department | Department of Industrial Systems Engineering (DISE) |
| Academic Program/FoS | Industrial Systems Engineering (ISE) |
| Chairperson(s) | Afzulpurkar, Nitin V. |
| Examination Committee(s) | Bohez, Erik L.J.;Chumnarn Punyasai;Ashraf, Muhammad Waseem |
| Scholarship Donor(s) | Asian Institute of Technology Fellowship |
| Degree | Thesis (M. Eng.) - Asian Institute of Technology, 2012 |