Design simulation and fabrication of a MEMS based spiral microchannel using inertia coupled dielectrophoresis technique for cell separation | |
| Author | Kalita, Zahnupriya |
| Call Number | AIT Thesis no.ISE-12-59 |
| Subject(s) | Dielectrophoresis Cell separation Microfluidics |
| Note | A thesis submitted in partial fulfillment of the requirements for the d egree of Master of Engineering in Mechatronics, School of Engineering and Technology |
| Publisher | Asian Institute of Technology |
| Series Statement | Thesis ; no. ISE-12-59 |
| Abstract | This project ma inly deals with the design of a microparticle separation system. The separation is done based on the principles of inertial microflu idics and dielectrophoresis. At high flow rate, the Lift force act on the particles. Another force , called the Dean drag force also act on the p articles due to the curved shape of the microchannel. The interplay of these two forces focuses the particles into separate streams based on their sizes. The D ielectrophoretic force due to the applied voltage also acts to equilibrate the particles along th e channel walls according to their size and polarizibility. The design used for this technique of separation is a spiral shaped microchannel. The microchannel is a 2 loop Archimedean spiral with a rectangular cross section of 500μm width and 80μm height. The numerical simulation for the separation of polystyrene particles of sizes 4μm, 14μm and 25μm are done with the CFD ACE+ software of the ESI CFD products. The fabrication of this device is done using the Photolithograp hy technique with PDMS . Metallic ne edles are inserted at the inlet and the outlets and connected to DC supply to get the required voltage at the specific flow rate. This microparticle separator device can be easily integrated into Lab - on - a - chip devices. |
| Year | 2012 |
| Corresponding Series Added Entry | Asian Institute of Technology. Thesis ; no. ISE-12-59 |
| Type | Thesis |
| School | School of Engineering and Technology (SET) |
| Department | Department of Industrial Systems Engineering (DISE) |
| Academic Program/FoS | Industrial Systems Engineering (ISE) |
| Chairperson(s) | Afzulpurkar, Nitin V. |
| Examination Committee(s) | Bohez, Erik L.J.;Chumnarn Punyasai;Ashraf, Muhammad Waseem |
| Scholarship Donor(s) | Asian Institute of Technology Fellowship |
| Degree | Thesis (M. Eng.) - Asian Institute of Technology, 2012 |