| Author | Parajuli, Deepak |
| Note | A thesis submitted in partial fulfillment of the requirements for the
degree of Master of Engineering in
Industrial and Manufacturing Engineering, School of Engineering and Technology |
| Publisher | Asian Institute of Technology |
| Abstract | The field of tissue engineering has developed to meet the tremendous need for organs and tissues. In the most general sense, tissue engineering seeks to fabricate, living replacement parts for the body. In order to fulfill the cycle of tissue engineering the scaffolds need to introduce which can be fabricate via various techniques. However, the scaffold created form these techniques are not sufficiently acquired with required properties. Therefore, the concept of integrating of rapid prototyping and electrospinning has developed. Furthermore, based on this concepts the machine has developed which is known as electrospinning based RP system and it is able to fabricate the controllable pattern scaffolds by controlling the appropriated parameters of fiber forming process.
Numerous experiments has been conducted to reduce the diameter of fiber and able to achieved in the range of 100-110 μm for single pattern. By varying the certain parameters shows the possibility of further improvement in fiber sizes. The study aims to explore these possibilities of further improvement in fiber sizes by referring the several techniques form the literature reviews. The experiments were conducted by controlling the parameters initial polymer concentration, needle size and fabricating conditions.
The experiments result shows that that these parameters has significant effect in fiber sizes. It has been proven that the smallest size of fiber can formed at 70% concentration level. Also the interesting things was that the fiber formed with blowing the compress air inside the experimental zone is suitable to form a fine fiber. In addition, the experiments suggested to use smallest needle size to form a fine fiber. At last but not least, the scaffold properties can be improved further by increasing the machine performance as well as by adding some suitable additives in solution to increase the stiffness of fiber. |
| Year | 2015 |
| Type | Thesis |
| School | School of Engineering and Technology (SET) |
| Department | Department of Industrial Systems Engineering (DISE) |
| Academic Program/FoS | Industrial Systems Engineering (ISE) |
| Chairperson(s) | Pisut Koomsap; |
| Examination Committee(s) | Huynh Trung Luong ;Pitt Supaphol; |
| Scholarship Donor(s) | Thailand (HM King); |