Controlled drug delivery from chitosan-alginate microcapsules | |
| Author | Bhopatkar, Deepak |
| Call Number | AIT Thesis no. BP-00-02 |
| Subject(s) | Chitosan Microencapsulation |
| Note | A thesis submitted in the partial fulfillment of the requirements for the degree of Master of science, School of Environment, Resources and Development |
| Publisher | Asian Institute of Technology |
| Series Statement | Thesis ; no. BP-00-02 |
| Abstract | ln this study chitosan-alginate beads have been investigated for applicat ion as a matrix system for controlled release of pharmaceuticals. Most of the drugs like peptides, antibacterial and antibiotics. which are sensitive for enzymatic degradation in the gastrointestinal tract needs to be protected for improving the bioavailability of drug. One of the best alternative approaches is to encapsulate a drug in microcapsules system. Microencapsulation comprises various technologies that can be used to coat small particle of solid or liquid dispersion with a thin coating layer. Microencapsulation of drug in sodium alginate I calcium chloride matrix has been studied extensively. In this work the marine polymer chitosan is used along with sodium alginate and calcium chloride to improve encapsulation abil ity and for sustai ned drug delivery in silu. Chitosan- alginate beads were prepared by dropping sodium alginate solution in the homogenous mi xture of calcium chloride and chitosan. A study had been conducted on effect of various process parameters on the bead quality. It was found that chitosan concentration, nature of drug and po lymer: drug ratio has significant effect on shape, encapsulation ability and release of drug. Release studies was done in phosphate buffer (pH:::7 .2) at 3 7°C. The methods of drying of beads also effects the release of the drug. In general the freeze dried beads shows faster release than the air dried beads. Beside this, release of drug was checked in di sti lled water. drug release was observed for one week. Post coagulation treatment of beads either with low molecular weight chitosan or 5% ·aoH so far did not shov,; a significant effect on the release of model drug bovine serum albumin (BSA). |
| Year | 2000 |
| Corresponding Series Added Entry | Asian Institute of Technology. Thesis ; no. BP-00-02 |
| Type | Thesis |
| School | School of Environment, Resources, and Development (SERD) |
| Department | Department of Food, Agriculture and Natural Resources (Former title: Department of Food Agriculture, and BioResources (DFAB)) |
| Academic Program/FoS | Bioprocess Technology (BP) |
| Chairperson(s) | Stevens, Willem F.; |
| Examination Committee(s) | Suwalee Chandrkrachang;Rakshit, Sudip K.;Pakorn Nuchnoi; |
| Degree | Thesis (M. Sc.) - Asian Institute of Technology, 2000 |