1 AIT Asian Institute of Technology

Application of chitosan membrane for drug delivery

AuthorBoldyn, Delger
Call NumberAIT Thesis no. BP-00-03
Subject(s)Chitosan

NoteA thesis submitted in partial fulfillment of the requirements for the Degree of Master of Science, School of Environment, Resources and Development
PublisherAsian Institute of Technology
Series StatementThesis ; no. BP-00-03
AbstractThis study has been done to develop the chitosan membrane system with loading drugs and their sustained release. Some teclrniques have been developed to load salicylic acid in chitosan membrane. The drug loaded chitosan membrane has been characterized for swelling index. The swelling index decreased with the increase degree of deacetylation of chitosan. The release rate of drug from single layer membrane is faster in the first initial half an hour than the later hours. Release of drug from double layer membrane was sustained with increasing the viscosity of chitosan solution. The 100 % release of salicylic acid occurred in 12 hours (235 cps viscosity), in 7 hours (151 cps) and in 2.5 hours (48 cps) from double layer chitosan membrane systems. With increasing the thickness of chitosan membrane, the release of drug was retarded. Sodium alginate membrane over the drug loaded chitosan gave better results than single layer chitosan membrane. Release of salicylic acid through chitosan and sodium alginate membranes were studied. With increasing concentration of calcium chloride used for hardening of sodium alginate membrane release of drug was sustained.
Year2000
Corresponding Series Added EntryAsian Institute of Technology. Thesis ; no. BP-00-03
TypeThesis
SchoolSchool of Environment, Resources, and Development (SERD)
DepartmentDepartment of Food, Agriculture and Natural Resources (Former title: Department of Food Agriculture, and BioResources (DFAB))
Academic Program/FoSBioprocess Technology (BP)
Chairperson(s)Suwalee Chandrkrachang;
Examination Committee(s)Stevens, Willem F.;Rakshit, Sudip K.;Pakorn Nuchnoi;
Scholarship Donor(s)Asian Development Bank;
DegreeThesis (M.Sc.) - Asian Institute of Technology, 2000


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