In-vitro study of prolonged drug release from calcium alginate-chitosan complex by coating theophylline commercial tablets | |
| Author | Mohanty, Biswa Ranjan |
| Call Number | AIT Thesis no. BP-02-03 |
| Subject(s) | Drug delivery systems Chitosan |
| Note | A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science, School of Environment, Resources and Development |
| Publisher | Asian Institute of Technology |
| Series Statement | Thesis ; no. BP-02-03 |
| Abstract | An in-vitro study was conducted to develop a prolonged drug release system based on calcium alginate-chitosan matrix by coating commercial theophylline tablets and investigating dissolution profile. Theophylline is an extensively used broncho-dilator with a half-life of 5-8 hours. Due to its narrow therapeutic level, it should be applied preferentially in a well-controlled and prolonged delivery system. The spray coating technique was followed to coat the commercial theophylline tablets imparting a calcium alginate-chitosan complex using different types cross-linking agents in order to convert the ready-made tablets in to retard form. Several operational parameters and chitosan: crosslinker ratios were investigated in order to establish an optimum di ssolution characteristic for prolonged drug release. It was found that type and concentration of chitosan and crosslinking agents, type of acid solvent and polymer: cross-linker ratio has significant effect on coating ability, texture of the tablet and prolongation of the drug diffusion rate. The drying condition of tablet was also found to play an important role in this current study of tablet coating. Release studies were done in simulated gastric fluid (pH := 1.2) and simulated intestinal fluid (pH :::7.4) at 37±1°C and 80 rpm. The size of the chitosan complex coated tablets over original theophylline tablet were increased 5.5-6 .0 % approximately in diameter and 22-22.5 % approximately in thiclmess. It was found that a lower chitosan concentration ( 1.0% w/v) shows more prolongation of drug \vhen coated alone but when treated with other cross-linkers, the chitosan: cross-linker ratio (2 .0%: 2. 0%) resul ted efficient delay in drug release. The calcium salts i.e. calcium chloride with concentration 4% maximized the delay in drug diffus ion rate. The drying of tablets at 40-42°C in dry oven further optimized the sustained drug release system to the tablet. |
| Year | 2002 |
| Corresponding Series Added Entry | Asian Institute of Technology. Thesis ; no. BP-02-03 |
| Type | Thesis |
| School | School of Environment, Resources, and Development (SERD) |
| Department | Department of Food, Agriculture and Natural Resources (Former title: Department of Food Agriculture, and BioResources (DFAB)) |
| Academic Program/FoS | Bioprocess Technology (BP) |
| Chairperson(s) | Stevens, Willem F.; |
| Examination Committee(s) | Suwalee Chandrkrachang;Preeda Parkpian;Satit Puttipipatkhachorn; |
| Scholarship Donor(s) | The Royal Netherlands Government; |
| Degree | Thesis (M.Sc.) - Asian Institute of Technology, 2002 |