Development and evaluation of e-LIPOSOME for controlled delivery of bioactive compounds in cosmetic application | |
| Author | Jirateep Chusri |
| Call Number | AIT Thesis no.FB-20-05 |
| Subject(s) | Liposomes Antioxidants Bioactive compounds |
| Note | A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Food Engineering and Bioprocess Technology, School of Environment, Resources and Development |
| Publisher | Asian Institute of Technology |
| Series Statement | Thesis ; no.FB-20-05 |
| Abstract | The current cosmetic industry is highly competitive, resulting in higher growth rates as well. The growth rate indicates the competitiveness of both large and small manufacturers. The important thing that makes the products different was the integration of various technologies into the cosmetic products. Studies on nanotechnology have discovered that emulsion system with small molecules of drug molecules and bioactive substances can easily penetrate into the dermis or target cells than large molecule. However, an important problem with the emulsion system is the instability of the system that make emulsions are easily damaged by inappropriate environments. This research therefore focused on the development of a new bioactive substance transport system that had received attention in recent years are the combination of emulsion and liposome systems call e-Liposome. In this experiment two bioactive substances including coenzyme Q10 and vitamin C were used as bioactive compound. The results showed that the production of nanoemulsions tween 80, propylene glycol, olive oil and distilled water showed emulsion mixed via a highpressure homogenizer lead to large average molecular size was amount 900nm. Then reduce the droplets size by using ultrasonication found that the size has significantly decrease on average 100nm. In addition, the increase in the Hydrophilic–lipophilic balance value can affect on the molecular reduced. The development of the e-Liposome system was successful because it was able to seen olive emulsion molecules inside the liposome vessel under the TEM microscope. The results of storage 28 days under 1000lux of light showed that e-Liposome significantly increase the stability by rate of size increase slower than nanoemulsion. For the antioxidant activity e-Liposome was noะ significant differences of e-Liposome and nanoemulsion in antioxidant activity on the 28th of storage. |
| Year | 2020 |
| Corresponding Series Added Entry | Asian Institute of Technology. Thesis ; no.FB-20-05 |
| Type | Thesis |
| School | School of Environment, Resources, and Development (SERD) |
| Department | Department of Food, Agriculture and Natural Resources (Former title: Department of Food Agriculture, and BioResources (DFAB)) |
| Academic Program/FoS | Food Engineering and Bioprocess Technology (FB) |
| Chairperson(s) | Anal, Anil Kumar; |
| Examination Committee(s) | Loc Thai Nguyen;Bora, Tanujjal; |
| Scholarship Donor(s) | Royal Thai Government Fellowship; |
| Degree | Thesis (M. Sc.) - Asian Institute of Technology, 2020 |