Studies on gold nanoparticle decorated zinc oxide nanorod-based LSPR sensor for the detection of ampicillin residues in water | |
| Author | Khajohnpat Teerasitwaratorn |
| Call Number | AIT Thesis no.ISE-21-24 |
| Subject(s) | Gold--Surfaces Nanotechnology Antibiotic residues--Environmental aspects |
| Note | A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Nanotechnology |
| Publisher | Asian Institute of Technology |
| Abstract | The antibiotic contamination of water is one of the modern-day global concerns causing various adverse effects on humans and other living organisms. Consequently, their detection in the aquatic environment is important to ensure a healthy environment around us. In this research, we report a localized surface plasmon resonance (LSPR) based aptasensor capable of detecting trace amounts of antibiotic residues present in water. The LSPR-based aptasensor is composed of nanoscale gold (Au) particles decorated on vertically aligned zinc oxide (ZnO) nanorods where the gold nanoparticles are functionalized with aptamer specific to bind ampicillin antibiotics to the sensory surface. The study focuses on the design of the aptasensor and the effects of amounts of ZnO and Au on the sensor performance. The sensor materials are characterized with scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and UV-Visible spectroscopy to investigate their morphology, elemental compositions, and optical properties. The developed LSPR-based aptasensor showed good sensitivity and selectivity towards ampicillin detection in water with a limit of detection close to 10 ppm concentrations of ampicillin within 20 minutes of analysis time. Results from this study showed future potential for the LSPR-based aptasensors in antibiotic detection which can offer inexpensive fabrication, high sensitivity, good selectivity, fast detection, mobility, and real-time detection. |
| Year | 2021 |
| Type | Thesis |
| School | School of Engineering and Technology (SET) |
| Department | Department of Industrial Systems Engineering (DISE) |
| Academic Program/FoS | Industrial Systems Engineering (ISE) |
| Chairperson(s) | Bora, Tanujjal |
| Examination Committee(s) | Loc Thai Nguyen;Mohammed, Waleed |
| Scholarship Donor(s) | Royal Thai Government Fellowship |
| Degree | Thesis (M. Sc.) - Asian Institute of Technology, 2021 |